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More serious but rare risks include pancreatitis and gallbladder complications, which require prompt medical attention if symptoms arise

This metabolic symbiosis exhibits biphasic regulation: LNCaP cells upregulate Gln catabolic pathways (e.g., GLS1-dependent glutaminolysis), while CAFs activate extracellular matrix (ECM) remodeling pathways

These patterns act as ligands for pattern recognition receptors (PRRs) expressed on the microglial surface, most notably Toll-like receptors 2 and 4 (TLR2 and TLR4) and triggering receptor expressed on myeloid cells 2 (TREM2) [54]

Most patients with first dose reactions did not have reactions after their second dose