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Xanthine dehydrogenase 1 (XDH1) produces ROS with NADPH oxidase in leaf epidermal cells, and the clearance of H 2 O 2 in mesophyll cells by XDH1 protects plants from oxidative damage (Ma et al., 2016)

Weakness and numbness in the hands and feet: Vitamin B12 deficiency can cause nerve damage, which can result in numbness or tingling in the hands and feet, as well as muscle weakness

Chemical Modifications: Certain peptides (e.g., acetylated, PEGylated) are chemically altered for stability or extended effects

Grade 2 events were nasopharyngitis in 1 HV in the 0.1 mg/kg cohort and gastroenteritis and staph skin infection in 1 HV in the 6 mg/kg cohort