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Despite the limited biosynthesis capability of the RBC, some endogenous GSH is still synthetized in the cytosol through two ATP-dependent reactions catalyzed by two different enzymes, glutamate cysteine ligase and glutathione synthase [13]

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Enhanced with complementary antioxidants

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Mice with hepatic GSH depletion exhibited increased food intake compared with controls (Figure 1E), while body weight, physical activity, and energy expenditure remained unchanged (Figure 1F and Supplemental Figure 1, G and H)