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Yes, most research indicates that standard oral glutathione is broken down by digestive enzymes before it can be used by the body

Chem Res Toxicol 36:13741385

Increases in lipid metabolites, carboxylic acids, and amino acids, particularly L-leucine and hypoxanthine in patients upon resolution of oral candidiasis following antifungal treatment suggests fungal clearance, immune activation and recovery from oxidative stress

Months or even years after recovering from an initial viral infection, many people find themselves fighting a daily, exhausting battle against debilitating symptoms