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To test the functional involvement of M2 macrophages in fibrotic pathology, we first induced macrophage polarization in vitro by using LPS or IL-4 into either M1 or M2 phenotypes, respectively (Additional file 1: Figure S3)

These changes correlate with increased GSH levels and decreased ACSL4 expression, thus mitigating ferroptotic cell death in IL-1stimulated chondrocytes and preserving cartilage integrity (187)

Sulforaphane Induces S-phase Arrest and Apoptosis via P53-dependent Manner in Gastric Cancer Cells

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Ascorbic acid (vitamin C) and -tocopherol (vitamin E) obtained mostly from diet are also important non-enzymatic erythrocyte antioxidants [19]