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For example, a tri-functional copper-based MOF nanozyme developed by Dong et al.not only generates ROS but also modulates the redox environment, overcoming chemotherapy resistance in CRC and providing a new therapeutic strategy for future clinical applications [101]

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This finding accounts for the important observation that the c-met binding affinity of LASSS/peroxynitrite-treated HGF (at the 1:8000:2000 molar ratio to HGF, with the wash-out of un-reacted free LASSS) was significantly higher than the original level of un-treated positive control HGF (Figure 2d, bars 2 and 6 )