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(Wan et al., 2016) found that the system could restore the NP phenotype following dedifferentiation through upregulating NP-specific genes ( KRT-8, KRT-18, FOXF-1 ) and the SAPH stimulated time-dependent increases in aggrecan and type II collagen deposition (Figure 7)

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Yago T, Petrich BG, Zhang N, Liu Z, Shao B, Ginsberg MH, McEver RP (2015) Blocking neutrophil integrin activation prevents ischemiareperfusion injury