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For example, Au@DTDTPA(Gd) NPs combined with X-ray radiotherapy significantly inhibit the invasive capacity of escape cells from GBM spheroids, and attenuate their invasiveness and stem cell-like characteristics (such as SOX2 downregulation) by reducing MMP-2 secretion and activity and inducing mitotic catastrophe (150)

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Yanagida K, Shimizu T

In the CC of cuprizone-treated mice the expression of the IGF-1 mRNA started to be up-regulated after 2 weeks of cuprizone feeding (Gudi et al., 2011) and peaked at weeks 45 corresponding to the maximal demyelination, proliferation of OPC and onset of their differentiation (Gudi et al., 2011)

Older Adults: Age-related changes, like decreased stomach acid, hinder B12 absorption from food