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Studies of the long-term consequences of the use of I on the occurrence and development of AITD clearly demonstrated that the early increase in thyroid antibodies is mostly transient, differs between populations under the influence of genetic and environmental factors, and does not always coincide with the presence of AITD or its further development (54)

Neurotransmission alterations Another pathogenic mechanism in HE associated with energy disturbances is the alteration in neurotransmission systems, such as the glutamatergic and GABA-ergic systems, resulting in neuronal disinhibition (mechanism described in Fig

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