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NNMT is a cytosolic enzyme that is primarily expressed in the liver and catalyzes the transfer of methyl group from the cofactor S-(5-adenosyl)-L-methionine (SAM) to other substrates

As research has shown 7 , alcohol consumption - especially heavy, episodic drinking - leads to a measurable increase in inflammatory markers

Interestingly, NRX can indirectly promote -catenin signaling by modulating Dvl stability

The primary role of GSTs is to detoxify xenobiotics by catalyzing the nucleophilic attack by GSH on electrophilic carbon, sulfur, or nitrogen atoms of said nonpolar xenobiotic substrates, thereby preventing their interaction with crucial cellular proteins and nucleic acids

Faria, A., & Persaud, S