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However, the effectiveness of this method is still controversial, as many of the bodys tissues must break down glutathione into L-cystine before it can be absorbed into cells (in which case, it could be more cost-effective to use n-acetyl-cysteine to supplement glutathione with higher reliability and probably cheaper cost)

GPX4 protein expression was significantly decreased whereas ALOX15 expression was significantly increased in the testes of 8-month-old S8/ Gss / mice (Fig