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11,12 NAPQI binds to housekeeping proteins, glutathione peroxidase (GPx), 13 and adenosine triphosphate (ATP) synthase, 14,15 among other proteins often abundant in mitochondria

This is supported by Yu et al.s work demonstrating that baicalin induced apoptotic cell death in HepG2 and SMMC-7721 cells (HCC lines), which was accompanied by upregulation of Bax, downregulation of B-cell lymphoma-2 (Bcl-2), and cleavages of Caspase-9, Caspase-3, and poly (ADP-ribose) polymerase (PARP) (Yu et al., 2015)

Both lithium and valproate have neuroprotective effects based on protection from glutamatergic neurotoxicity by inactivation of NMDA receptors, on activation of cell survival factors such as phosphoinositide 3-kinase/protein kinase B pathway, and on induction of neurotrophic and neuroprotective proteins

A 2023 review in Drug and Therapeutics Bulletin concluded that for healthy adults, evidence beyond rehydration is limited

I., Murphy, M