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Frezza V, Fierro C, Gatti E, Peschiaroli A, Lena AM, Petruzzelli MA, et al

In cases where encapsulation efficiency is low, patients may not receive the intended dose of the drug, leading to suboptimal treatment efficacy [343]

In addition, while we have categorized HDTs into two broad groups based on their primary effects(1) decreasing TB burden and (2) reducing tissue damageit is important to note that some HDTs can simultaneously address both aspects