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The exposure to LPS was associated with increased number of total cells (1.9x10 5 cells, 95% CI: 0.9x10 5 to 3.0x10 5 cells), whereas there were slightly lower numbers of total cells in the LPS-exposed mice that also received high-dose CB (-0.5x10 5 cells, 95% CI: -1.5x10 5 to 0.6x10 5 cells) relative to the LPS-exposed mice (Table 1)

In addition, TMT exposure can trigger neuroinflammatory responses, characterized by increased levels of pro-inflammatory cytokines such as TNF-, IL-1, and nitric oxide, and increased gene expression of the glial fibrillary acidic protein and activated microglia in the brain

In the electron transport chain (ETC), oxygen is partially reduced by the incorporation of an electron, generating a free radical as a secondary product (Venditti et al., 2013)

In other cell types, arginine synthesis by citrulline is very low but dramatically increases when inducible nitric oxide synthase (NOS) increases (Fig