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However, in this GSH/GSSG couple, one form reduced glutathione or GSH is more important than the other

Study has shown that Nrf2 is highly expressed in cancer tissues of NSCLC patients and can regulate the sensitivity of NSCLC cells to ferroptosis induced by Cys 2 deprivation [88]

Further, the treatment prevented degeneration of myelinated fibers and accentuated the axon circularity [51]

Therapeutically, we argue against indiscriminate antioxidant loading in favor of node-specific, compartment-targeted modulation (NOX/NOS tuning, mitochondrial QC/RET tempering, ER redox control, iron/ferroptosis management, calibrated sulfur-axis support), implemented as time-staged sequences and titrated to biomarkers

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