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As both DNA methylation and folate are important in mental health, reduction of MTHFR activity or folate deficiency have been associated with an onset of several psychiatric diseases 10 , schizophrenia, bipolar disorder, depression, autism, and ADHD

Based on these results, scientists at Tokushima University Hospital and Suzuka University of Medical Science, in Japan, conducted a long-term Phase 2/3 clinical trial (NCT00444613) to evaluate the efficacy and safety of ultra-high-dose methylcobalamin treatment for ALS