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They further refined the in vivo and in vitro experiments and found that andrographolide enhanced nuclear translocation of Nrf2 and increased the expression of antioxidant genes, alleviating APAP-induced liver oxidative stress damage in mice and reducing HSC activation (Yan et al., 2018b)

10.1002/jcb.30634 10 DongR.ZhangX.LiuY.ZhaoT.SunZ.LiuP.et al (2023)

Additionally, retinoic acid helps maintain collagen and elastin levels in tissues, organize extracellular matrix and basement membrane structures, and regulate TGF- levels, thereby inhibiting inflammatory processes [160,161,162,163,164,165,166]