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MIMOSA2: a metabolic network-based tool for inferring mechanism-supported relationships in microbiome-metabolome data

Curtis, Maria del Mar Malagon, Frances Y

doi: 10.1038/nature11814 75 KavranAJStuartSAHayashiKRBaskenJMBrandhuberBJAhnNG

This study will focus on some molecular targets, including Nuclear factor erythroid 2-related factor 2 (Nrf2), a regulatory nuclear factor that influences the activity and cellular response of the antioxidant system 17 , NF-B, and the inflammasome NLRP3 which are closely related to one another and influence the level of inflammatory and pro-fibrotic cytokines in the microenvironment as well as the apoptosis and senescence of alveolar epithelial cells especially for NF-B 18