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In the ventrolateral preoptic area, morphine reduces the firing rate and hyperpolarizes sleep-promoting neurons (as assessed by sensitivity to norephinephrine treatment) but has no effect on non-sleep-promoting interneurons (Wang et al., 2013)

FDAs introductory briefing document states that the agency does not intend to issue a final determination until it has considered input from the advisory committee process and finalized its reviews

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Among surviving patients, the most severely affected patients have intellectual disability, progressive cerebellar disease and ataxia, recurrent bacterial infections, and chronic metabolic acidosis and hemolytic anemia

Gastroenterology 150 , 194205 (2016)