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117 HSC activation causes a decline in SAM and MTA levels, a decrease in the SAM/SAH ratio, and overall hypomethylation of DNA

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This method provides a new paradigm for precision diagnosis and treatment of breast cancer and can be extended to multimodal therapies in the future ( 5.4 ATP-responsive MSNs ATP is a critical metabolic product in humans and its level will vary with the changes in a persons physiological status (Mo et al., 2014)