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If the GLP-1/GIP/glucagon receptor class shows disease-modifying behaviour in OA rather than just mechanical pain relief from weight loss, it expands the scientific rationale for the compound and reinforces the argument that the triple-agonist mechanism is doing more than suppressing appetite

Lower concentrations (e.g., 1mg/mL using 5mL water) improve measurement accuracy but require larger injection volumes and may reduce stability due to increased surface area exposure to oxygen