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doi:10.1155/2015/648108 Sakuma S, Ishimura M, Yuba Y, Itoh Y, Fujimoto Y

Vitamin B12 was discovered from its relationship to the disease pernicious anemia, which is an autoimmune disease that destroys parietal cells in the stomach that secrete intrinsic factor

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Common and potential side effects include: Skin irritation : Redness, itching, rashes, or allergic reactions where the patch sits, especially with daily use Cardiovascular effects : Bitter orange extract can increase heart rate and blood pressure Digestive issues : Green tea extract may cause upset stomach or headaches Sleep problems : Caffeine content from green tea extract can disrupt sleep Liver concerns : Garcinia cambogia has been linked to liver problems in some cases Unknown risks : Lack of regulation means uncertain ingredient quality and quantities The bigger concern is that these products arent regulated in the same way as prescription medications