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The common pathogenesis in blinding retinal diseases is retinal vascular leakage resulting from the loss of BRB integrity [34]

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Despite the initial feeling of energy it gives, alcohol affects judgment and inhibitions while slowing reaction times

J Diabetes 2016;8:286-94.ArticlePubMed 9

Abbreviations ATM Ataxia telangiectasia mutated ATR Rad3-related kinase bHLH Basic Helix-Loop-Helix CBP CREB binding protein ccRCC Clear cell renal cell carcinoma CDKs Cyclin-dependent kinases Co 2 Cobalt CODD C-terminal oxygen-dependent degradation domain C-TAD C-terminal transactivation domain DES Drug-eluting stents DUBs Deubiquitinases DXR Doxorubicin EAF2 ELL-associated factor 2 EGFR Epidermal growth factor receptor eIF4F Eukaryotic initiation factor 4F EMT Epithelial-mesenchymal transition EPO Erythropoietin Fe 2 Divalent iron FH Fumarase FIHs Factors inhibiting HIF GDH Glutamic dehydrogenase GPT Glutamic pyruvate transaminase HATs Histone acetyltransferases HDAC Histone deacetylase HIFs Hypoxia-inducible factors HNSCC Head and neck squamous cell carcinoma HREs Hypoxia-responsive elements HSPs Heat-shock proteins ID Inhibitory domain IDH Isocitrate dehydrogenase KLF Kruppel-like factor LDH Lactate dehydrogenase MAPK Mitogen-activated protein kinases mTORC1 Mechanistic target of rapamycin complex 1 NF-B Nuclear factor kappa-light-chain-enhancer of activated B cells Ni 2 Nickel NODD N-terminal oxygen-dependent degradation domain N-TAD N-terminal transactivation domain ODDD Oxygen-dependent degradation domain p70S6K P70S6 kinase PAD Peripheral arterial disease PAH Pulmonary arterial hypertension PAS-A Per-Arnt-Sim-A PAS-B Per-Arnt-Sim-B PHD Prolyl hydroxylase domain-containing protein pVHL Von HippelLindau tumor suppressor protein R-2-HG R-2-hydroxyglutarate ROS Reactive oxygen species RPS6 Ribosomal protein S6 S-2-HG S-2-hydroxyglutarate SDH Succinate dehydrogenase SP1 Specificity Protein 1 SIRT Sirtuin SUMO Small ubiquitin-like modifier TCA Tricarboxylic acid TFs Transcription factors TME Tumor microenvironment Trans-activation Transcriptional activation Ubl Ubiquitin-like UCHL1 Ubiquitin C-terminal hydrolase-L1 USPs Ubiquitin-specific proteases VACV Vaccinia virus VEGF Vascular endothelial growth factor KG -Ketoglutarate 2OGDD 2-Oxoglutarate-dependent dioxygenase 4EBP1 4E-binding protein-1 Author contributions Q.L