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at least three months before conception and throughout the first trimester of pregnancy The research concerning the underlying mechanism of the preventions of NTDs by FA currently focus on, for example: the abnormal folate metabolism, the Hcy metabolism [plasma and amniotic fluid ( tHcy ) is higher in NTD infants and their mothers], or variations in folate-related enzymes

This pharmacological strategy highlights the potential of targeting NAD+ metabolism to prevent or reverse age-related metabolic dysfunction

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