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302 , C1780C1785 (2012)

Studies indicate that PS exposure induces mitochondrial cristae fragmentation, reduces membrane potential, and inhibits electron transport chain complex activity in murine brainscollectively exacerbating ROS generation

Aging Dis 14:17781798

Structural and biophysical analyses demonstrated high-affinity copper binding to PDK1, enhancing its interaction with AKT and activating downstream -catenin signaling

For example, TGF- family ligands participate in cardiac remodeling after infarction via regulation of inflammation and repair [3] and excessive TGF- signaling can also lead to cardiac fibrosis [4]