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In the emerging field of proteomics, an essential step in understanding protein structure and function is to determine which proteins interact with each other, thereby identifying the relevant biological pathways

After fixation and washing, sections were immersed in fresh -gal staining solution and incubated at 37 C overnight

Acknowledgements The authors wish to thank Tara Foley, Dr Gerry Moloney, Patrick Fitzgerald and Dr

Kidney function tests, such as serum creatinine and creatinine clearance, are also routinely monitored to assess renal health, as Alimta is primarily excreted by the kidneys

Metabolites were eluted from the HILIC column using an increasing gradient of solvent B (Milli-Q water: 20 mM ammonium acetate, HPLC grade (85:15, v/v)) at 1 mL min 1