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DOI: Received: Accepted: Published: Publisher Name: Springer, Cham Print ISBN: 978-3-030-71519-9 Online ISBN: 978-3-030-71519-9 eBook Packages: Living Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

Ipamorelin acts on a separate receptor (GHSR rather than GHRHR), which is why researchers studying the GH axis frequently administer a GHRH analog and a ghrelin mimetic together see the CJC-1295 + Ipamorelin blend for a combined-compound research format

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Without clinical data, an absolute upper limit cant be established

The combined activation of all three pathways is hypothesised to produce more pronounced and sustained weight reduction, though the long-term clinical implications of each receptor's contribution remain to be fully established