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In 127 pairs of GIST located in the gastric, small intestine, and other tissues, 114 were positive for IDO (89.8%) expression, while 60 were positive for WRS (47.2%) ( ARSs-mutation related digestive system diseases Mutations in ARSs exhibit a close relationship with some inherited diseases in humans, which makes patients more susceptible to digestive system related phenotypes such as elevated liver enzymes and hepatomegaly (Prasun et al., 2019), liver steatosis (Kuo et al., 2019), liver cirrhosis (Xu et al., 2018), and advanced liver disease associated portal hypertension (Peluso et al., 2021)

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But glutamine also acts as nitrogen donor, being metabolized by enzymes involved in the synthesis of pyrimidine, including CAD and CTP synthetase

19 reported that impairment of acetylcholine-induced vasodilation, increase in NADPH oxidase activity and NADPH oxidase-induced ROS generation in saphenous veins in patients with cardiovascular diseases are related to each other and are associated with increased risk of atherosclerosis

Mechanistic confirmation using pathway-specific inhibitors or genetic models will be essential in future work to delineate the specific molecular targets underlying SPAEs protective actions