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Swisher S , Ajani J, Komaki R, Putnam J, Walsh G, Liao Z, Yao J, Faust J, Wu TT, Roth J, Study Group MER

MR-Egger method: OR = 0.51

GSH was shown to be the main inhibitor in the active site of the main protease (M pro ), the essential protein for virus invasion, and cysteine (Cys300) glutathionylation inhibits M pro activity by blocking its dimerization supporting the use of GSH in COVID-19 patients (Davis et al., 2021

It has been documented that BP from a corn tree ( Quercus acutissima ) is reported as an excellent antioxidant and anti-melanogenesis agent due to the presence of high amount of phenolic acids, and its possible mode of action is the obstruction of melanin-producing enzyme (tyrosinase) ( On the other hand, free phenolics are digestible in the small intestine while bound phenolic compounds are not absorbed (in the small intestine) and reached in the large intestine where they pass the fermentation process (by colon microbiota) and liberate bound phenolic compounds

The increase in GSH content can be achieved from GSSG through GR catalyzation or de novo biosynthesis through the -glutamyl cycle