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Despite significant progress in clinical RNAi drug development, there remains considerable room for improvement in pharmacokinetics, pharmacodynamics, and strategies to mitigate toxicity (Setten et al., 2019)

Painful diabetic neuropathy: many similarly effective therapies with widely dissimilar costs

Ice crystals that form during freezing physically shear peptide bonds, similar to the damage caused by vigorous shaking

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Some medical conditions, including autoimmune disease like shingles (herpes zoster), rheumatoid arthritis or celiac disease, as well as Lyme disease, some cancers, and several other diseases can also cause or increase the risk of nerve damage, also sometimes referred to as peripheral neuropathy