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however, there were no significant changes in fasting insulin and insulin sensitivity index between groups [37]

FIGURE 5 2.2.10.1 In vitro Cellular Studies Regarding its antifibrotic potential, cell culture experiments on human lung fibroblasts and alveolar epithelial cells have revealed that PFD is able to inhibit fibroblast proliferation, myofibroblast differentiation, collagen synthesis, fibronectin production, deposition of ECM components, and -SMA and HSP47 expression (Nakayama et al., 2008