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Development of a rapid screen for the endodermal differentiation potential of human pluripotent stem cell lines

Cultures are then co-incubated with various doses of the test compounds and either cisplatin or an aminoglycoside at varying doses for 12 to 96 hours

Patients considering combination approaches should understand that this represents an unproven strategy that increases cost and injection burden without documented benefit

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In some embodiments, the otic formulation or composition comprises between about 0.01% to about 25% by weight of the carbomer