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These data suggest that circulating IGF-1 is critical for the modeling of bone, particularly periosteal growth (even more than linear growth, since femoral length of the LID and ALSKO mice was only slightly affected)

The nanoparticle concentration (100 mg L 1 ) and weekly foliar application schedule were selected based on our previous study [11] and preliminary trials showing that this dosage produced consistent responses without phytotoxic effects

Science 387, 850858

biochemical evidence of a shunt, etc) should be taken into account, emphasizing that clinical pathologic data should never be interpreted in isolation