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As ArfGAP1 is required for LRRK2-induced neuronal toxicity, and ArfGAP1 silencing in neurons is generally well-tolerated [16, 17], ArfGAP1 inhibition may offer an alternative therapeutic target for attenuating LRRK2 activity and toxicity in PD

Glutathione deficiency is associated with both the development and progression of Parkinson's disease, and supplementation with GSH is being explored as a potential therapeutic strategy

The strategy of the genes

The arm is held in slight abduction and in external rotation

Lu YX, Ju HQ, Liu ZX, Chen DL, Wang Y, Zhao Q, Wu QN, Zeng Zlei, Qiu HB, Hu PS, Wang ZQ, Zhang DS, Wang F, Xu RH (2018) ME1 regulates NADPH homeostasis to promote gastric cancer growth and metastasis