glutathione brain function Changes in levels of the antioxidant in and blood across the age span of healthy adults: A systematic review Frontiers | The role of

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PMID: 10657910

Maes et al., 2011), and reduced activity of the antioxidant glutathione (GSH) in postmortem brain samples (Gawryluk et al., 2011)

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Strategies aimed to increase cytosol GSH (e.g., NAC) may not be an optimal approach for boosting mGSH and therefore for treatment of SH or AD, as it would result in mainly increasing cytosol GSH without replenishing mGSH levels A new approach has been exploited recently in several contexts by the development of a series of cationic antioxidants targeted to mitochondria, including derivatives of the endogenous antioxidants ubiquinol (MitoQ), alpha-tocopherol (MitoVit E), and of the synthetic spin trap PBN (MitoPBN