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Once activated, Drp1 translocates to the mitochondrial outer membrane, where it assembles with adaptor proteinssuch as FIS1, MFF, MID49, and MID51to form a GTP-driven contractile ring that mediates mitochondrial scission (Pfluger et al., 2015)

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[] showed that madecassoside could reduce the inflammatory response caused by the activation of the NLRP3 inflammatory complex and the joint action of NLRP3, ASC, and caspase-1