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Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions

In summary, future therapeutic innovations should move beyond simple immune suppression to a more integrated model that addresses oxidative stress, adaptive immunity, and innate immune amplification simultaneously

Importantly, FOXO4-DRI showed no significant toxicity towards normal TM3 Leydig cells, demonstrating its selective action against senescent cells