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Disclosure of interest: Joan McCormack: Nothing to Disclose, Olga Brych: Nothing to Disclose, Ronan Collins: Nothing to Disclose, Tim Cassidy, Nothing to Disclose, Joseph Harbison: Nothing to Disclose

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3 The deterioration of -cell function is a key contributor to the progression of T2DM and involves several interrelated pathogenic mechanisms, including glucotoxicity, lipotoxicity, endoplasmic reticulum (ER) stress, oxidative stress, and chronic low-grade inflammation

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Conversely, dysregulation of autophagy is implicated in numerous diseases: Cancer: Both a tumor suppressor and a survival mechanism for cancer cells