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Metabolic and endocrine factors are also at play

Alterations in energy metabolism in cardiovascular diseases often involve systemic pathophysiological changes across multiple systems, while the key energy metabolic targets (AMPK, SIRT) exhibit functional variances in different tissues, suggesting the need for in-depth mechanistic exploration using tissue-specific animal models and expanding clinical research in the future

The presence of macrophages in VAT contributes significantly to this phonotype

however, the most sensitive and specific ones remain too expensive for widespread use

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