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The inclusion criteria emphasized the following: (1) Mechanistic studies that explore NACs neuromodulatory effectsspecifically its impact on oxidative stress, neurotransmission, and neuroinflammatory signalingin both in vitro and in vivo models

119 NaclerioRAnsoteguiIJBousquetJCanonicaGWDAmatoGRosarioNet al

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Five studies of BPC-157 reviewed by the agency "were of short duration, had small sample sizes and evaluated doses that were likely exploratory in nature," the staffers said