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All six complexes had comparable Glide energy scores ranging from 36.024 to 30.592 kcal/mol

This effector immune mechanism involving cytokines has received extensive attention in APAP-induced hepatotoxicity, in which DAMPs released by damaged hepatocytes act on pattern recognition receptors (PRRs) on macrophages and other potential cells, causing the production of pro-inflammatory cytokines and chemokines, thus promoting the inflammatory response [173]

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