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The Pentose Phosphate Shunt Provides Reducing Equivalents For Reductive Biosynthesis And Maintaining An Intracellular Reducing Environment The activity of the oxidative phase of the pentose phosphate shunt is low in muscle, but high in liver, testis, adrenal cortex, and mammary gland, where NADPH is used in the synthesis of fatty acids or steroids, and in red blood cells, which are exposed to strongly oxidizing conditions as a result of their oxygen carrying function and use NADPH generated by the pentose phosphate shunt to counteract their oxidizing environment

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Vitamin B12 is a nutrient commonly found in animal-based foods, so individuals who follow a vegetarian or vegan diet may be at a higher risk for Vitamin B12 deficiency