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Figure 1 Because of the alteration of physiological or pathological conditions in the human body, the cellular copper content changes, resulting in the disturbance of copper homeostasis, namely, copper excess or copper deficiency

doi:10.1186/s13287-022-02831-1 [2] McCoy AT, Benoist CC, Wright JW, et al

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This review is part of a larger project, and we present this companion review, which provides a detailed examination of the literature beyond polyphenols and/or phytoestrogens for estrogen-deficient skin