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Cuskelly GJ, Mooney KM, Young IS

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Methylcobalamin is the most active, absorbable form of B12

All patients received a standard lifestyle intervention which included instruction on a reduced-calorie diet (approximately 500 kcal/day deficit) and increased physical activity counseling (recommended minimum of 150 min/week) that began with the first dose of ZEPBOUND, during the lead-in period, and continued throughout the trial

This protection extends to spinal cord integrity, preserving motor function in 65-70% of at-risk individuals