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That figure came from an assay-specific in-vitro spine-density assay (picomolar Dihexa versus nanomolar BDNF) and does not mean Dihexa is millions of times more effective in a living brain

& Hazen, S

The strong reduction of Iba1 is particularly noteworthy because human and animal studies have shown that microglia can be chronically activated for weeks to years after brain trauma (Gentleman et al, 2004

Considerations and practicalities Invasive component : Self-administration requires sterile preps, sterile needles, proper injection sites, disposal of sharps, etc

And long-term safety studies in humans would address the most significant remaining uncertainty about the compound