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Graf and Kastins review catalogues a strikingly broad reported activity profile effects on stress tolerance, pain, thermoregulation, endocrine secretion, and withdrawal states while concluding that the physiological functions and mechanism remain to be established. [2] Schneider-Helmert and Schoenenberger similarly reported that DSIP raised alertness and performance during the waking state and appeared to modulate stress tolerance and coping

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And, sure, it looks promising in animals, but lets look at this one study done in humans, published in 2021 in an obscure journal that focuses on alternative medicine

Second, the problem may also be resolved by improving BDNF delivery into the target region

No evidence supports the commercial subcutaneous route evaluated by FDA