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Subcutaneous tissue is abundant in G protein-coupled receptors that play a crucial part in maintaining fat balance by regulating the release of lipolysis, adiponectin, and leptin (20)

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However, it does not fully address the potential unintended effects, such as toxicity or interference with other cellular pathways

J Mol Biol 385: 12571265 Chen PT, Chen ZT, Hou WC, Yu LC, Chen RP (2016) Polyhydroxycurcuminoids but not curcumin upregulate neprilysin and can be applied to the prevention of Alzheimer's disease