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Renal Effects In the kidney, prostaglandins, produced by both COX-1 and COX-2, are important regulators of sodium and water reabsorption through PGE2 and of renal function and hemodynamics via PGI2 in response to vasoconstrictive factors (e.g., endothelin-1, a factor that increases peripheral vascular resistance) and through effects on the renin-angiotensin system

doi: 10.1021/acs.molpharmaceut.5c00761 256 SweeneyM

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[DOI] [PMC free article] [PubMed] [Google Scholar] 28.Rimland B

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