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Ferritin plays many roles in sensing and regulating cellular iron levels ( Fth1 knockout caused a reduction in renal fibrosis compared to the wild-type control (Supplementary Figure S2B)

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Carnitine has also been scientifically shown to speed up the weight loss process in obese housecats [6]

Moreover, the key oncogenic signaling pathways in TC (such as PI3K-AKT, MAPK, Wnt/-catenin, and HIF-1) can indirectly affect the activity of DNMT and TET by regulating the levels of key metabolic intermediates (such as acetyl coenzyme A and -glutamine) [42]