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The pulsatile release is considered important for receptor sensitivity and downstream IGF-1 signaling

Nutr Neurosci 9:5761 Wu L, Zhang Q-L, Zhang X-Y, Lv C, Li J, Yuan Y, Yin F-X (2012) Pharmacokinetics and bloodbrain barrier penetration of (+)-catechin and ()-epicatechin in rats by microdialysis sampling coupled to high-performance liquid chromatography with chemiluminescence detection